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Key trials like STEP (Semaglutide Treatment Effect in People with obesity) showed 14.9-17.4% weight loss at 68 weeks versus 2.4% on placebo

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A landmark meta-analysis found that weight reduction of 5-10% resulted in spontaneous ovulation restoration in 55-100% of women with anovulation related to obesity

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Methods The protocol of this systematic review and meta-analysis is registered in PROSPERO (registration no

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