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Notably, IGF-1 promotes neurogenesis in the hippocampus, and reduced IGF-1 levels have been linked to depressive-like behaviors in animal models [97, 98]

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31 The overall TRIUMPH1 and TRIUMPH2 sample sizes provide at least 90% power to detect clinically meaningful weight reduction with retatrutide at 9 and 12 mg doses versus placebo on percent change in body weight, assuming each dose is analysed separately in parallel using a 2sample t test at a 2sided significance level of 0.0125