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Indirect evidence showed overall superiority over DPP-4 inhibitors, which appears to be a class effect.16,17 However, superiority between GLP-1 RAs and SGLT2 inhibitors varies across different outcomes

Below are the advantages and disadvantages of using Hers

Looking at the pipelines set out by major manufacturers, The Pharmaceutical Journal highlights some of the most promising and most novel approaches that could be rolled out to patients in the years to come, unpacking how they work and what benefits they could offer

Due to the potential of GLP-1R antagonists to modulate T-cell regulation and the evidence that enhancing T-cell infiltration can effectively transform cold tumors into hot tumors (2729), it is plausible that combining GLP-1R antagonists with ICIs may synergistically modulate T-cell-mediated immune sensitivity to improve tumor treatment outcomes

Their ability to reduce MACE (major adverse cardiovascular events) gives them a unique advantage over older therapies

3A and J) and vWF (Fig