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Receptor desensitization and tachyphylaxis When receptors are exposed to an agonist continuously, they can become less responsive over time
Changes in Lean Body Mass with Glucagon-Like Peptide-1-Based Therapies and Mitigation Strategies

A larger phase III trial involving hundreds or thousands of patients would be ideal to confirm these benefits

Exendin-4 decreases liver inflammation and atherosclerosis development simultaneously by reducing macrophage infiltration
First, adequate protein preserves lean muscle mass during weight loss
Jalewa J, Sharma MK, Gengler S, Hlscher C