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The SURMOUNT-3 study, after an organized intensive lifestyle intervention of 12-week, is a randomized 72-week clinical trial where patients receive placebo or TZP at the maximally tolerated dose

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For these patients, basal insulin alone may not be the preferred option

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While dehydration itself is not typically reported as a direct side effect in clinical trials, the risk stems from the common gastrointestinal side effects that can lead to fluid loss

This study found that GLP-1 treatment had a 2.11 HR of developing wet AMD: 0.2% of GLP-1 treated patients developed wet AMD compared to 0.1% of control