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Both oral and injectable semaglutide activate the same GLP-1 receptor, but their absorption pathways differ significantly

These effects were observed with central, but not peripheral, administration of the agonist and antagonist, suggesting receptor expression on the luminal, CSF-facing side of the choroid plexus, which aligned with GLP-1R-mediated modulation of luminally-expressed transporters in excised choroid plexus

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