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The juxtaposition of these models offers valuable insights into the structural dynamics of GLP-1R when bound to tirzepatide, which is crucial for therapeutic applications in diabetes and weight management

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Current perspectives on GLP-1 agonists in contemporary clinical practice from science and mechanistic foundations to optimal translation

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Tirzepatide reduces inflammation primarily through weight loss, and this effect could be beneficial in overweight, obese individuals and those with metabolic dysfunction (Sattar et al