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When the analysis included large studies at the licensed weight-loss dose of semaglutide (2.4 mg), the treatment effect remained approximately 5 mmHg

In addition, semaglutide use is not advised during pregnancy or breastfeeding, and women attempting to conceive should discontinue semaglutide medications at least two months prior to conception, as it can impact fertility.7 While there are typically no dose adjustments required for patients with renal or hepatic impairment, careful monitoring is advised for individuals who have had bariatric surgery

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Semaglutide reduces HbA1c, systolic blood pressure, and body weight.After 12 weeks of treatment, semaglutide decreased fasting and postprandial glucose by increasing insulin production and decreasing glucagon secretion (which is normally associated with increases in blood sugar)