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Christopher Newgard (Duke University, USA)

This hypothesized mechanism could enhance insulin secretion and suppress glucagon secretion in glucose-dependent manners (Figure 1)

The benefits of SGLT2i therapy also extends to CKD where there is a significantly reduced risk of decline in eGFR and progression to end stage renal failure, regardless of presence or absence of type 2 diabetes [23]

- Key news Takeda Pharmaceutical Ltd

Reedtz-Runge for critical review of the manuscript

Within one or two minutes the molecule gets dismantled by enzymes in the blood and cleared by the kidneys
