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When we think about oral formulations of novel weight management products, we need to keep in mind that they are absorbed from the small intestine, enter the portal vein, and are transported to the liver, which mimics physiological pathways of endogenous incretins sectered by various enteroencrine cells
In the most optimistic scenario, the use of GLP-1 agonists could lead to what we call virtue spirals. In these spirals, weight loss could lead to: Increased physical activity Healthier food choices Sustained weight management This positive feedback loop could influence more than just diet and exercise
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It establishes the clinical context in which downstream metabolic adaptation, altered nutrient intake, and long-term physiological tradeoffs should be interpreted
So, but specifically for obesity, I think it's in the vein, it's hard to, you should always be careful
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