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Animal studies showed increased rates of pregnancy loss, reduced birth weight, and some developmental abnormalities when tirzepatide was administered during organogenesis (the critical period of organ formation in early pregnancy)

Discontinuation of oral semaglutide occurred in 10% of patients over 6 months

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For individuals participating in retatrutide clinical trials, or for those following developments in this area ahead of potential future approval, understanding how to manage GI side effects is important