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In two double-blind trials, diarrhea was reported in 4% of pediatric patients 6 to 17 years of age with FC treated with LINZESS 72 mcg once daily, and 7% and 8% of pediatric patients 7 to 17 years of age with IBS-C treated with LINZESS 145 mcg and 290 mcg once daily, respectively

Media coverage, while raising awareness, sometimes oversimplified semaglutide's mechanism or downplayed common side effects like nausea, constipation, and appetite suppression

Clinical science

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Because of this, effectiveness is best evaluated on an individual basis rather than assuming one medication is universally better

Well-Characterized Side Effect Management Semaglutide's gastrointestinal side effect profile is extensively documented and manageable with established titration protocols