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Introduction Incretins are hormones secreted by intestinal cells in response to ingested nutrients that play a role in the regulation of glucose homeostasis

In rare cases, GLP-1 agonists like Ozempic have been linked with eye problems, gallbladder and pancreas problems, blocked intestines, and stomach paralysis (a condition in which your stomach muscles don't contract as they should to help you digest food)

3,130,219 GLP-1 also activates PKA and EPAC through a cAMP-dependent pathway

PDB-101: Protein Data Bank

doi: 10.2337/diab.47.1.57

Since satiety and reduced appetite are key contributors to weight loss, managing these symptoms while maintaining the therapeutic efficacy of GLP-1RAs should be carefully balanced