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Different areas have different tissue depths, nerve densities, and proximity to blood vessels

Qsymia, approved in 2012, combines an old stimulant, phentermine, with topiramate, an anticonvulsant medication

This could mean non-coverage for certain patients who are otherwise indicated for a particular drug or different degrees of coverage for patients stratified into various sub-groups

Evidence for body weight management For total body weight loss, all medications assessed showed clinically meaningful benefit versus placebo

Besides facilitating movement, muscles help absorb glucose (sugar) in response to insulin secreted after a meal

Ethics declarations Funding This study was funded by Novo Nordisk