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Early non-peptidic compounds such as TT-OAD2 provided initial proof that direct engagement of the TM pocket by small molecules could promote GLP-1R activation (Zhao et al., 2020)

Ann Surg 276(5):e417e424 Goldberg I, Nie L, Yang J, Docimo S, Obici S, Talamini M et al (2021) Impact of bariatric surgery on the development of diabetic microvascular and macrovascular complications

The downstream purification process is designed to remove these impurities

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And there is high likelihood that they are in fact unsafe for pregnancy since they greatly alter insulin signaling, which is a key process in pregnancy

Nature 454(7203):445454 Gonzlez-Pacheco H, Amezcua-Guerra L, Sandoval J, Arias-Mendoza A (2020) Potential usefulness of pentoxifylline, a non-specific phosphodiesterase inhibitor with anti-inflammatory, anti-thrombotic, antioxidant, and anti-fibrogenic properties, in the treatment of SARS-CoV-2