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Description
In recent years, the gut-brain axis has been increasingly considered a promising topic for the study of CNS-related diseases because the gut microbiota and gut hormones have been shown to interact with other organs including the brain (Knight et al., 2017), although the mechanisms involved in gut homeostasis and brain function are as yet uncharacterized (Neufeld and Foster, 2009)

Until recently, the only effective treatment for obesity was bariatric surgery, and a century of drug development for obesity can be essentially described as a failure until now

Neuroprogression happens

GLP-1 medications are not FDA-approved for Type 1 diabetes

(Chenopodiaceae)
Scientific Roadblocks The human skin is designed to keep large molecules out
