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GIP mediates the incretin effect and glucose tolerance by dual actions on cells and cells

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10.1097/PRS.0b013e31828bd3b3 27 CheungL.HanJ.BeilhackA.JoshiS.WilburnP.DuaA.et al (2006)

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This warning also includes concerns about hypercalcemia

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In the liraglutide group, 35% of the children experienced a BMI reduction of at least 10%, while only 4% was observed in children in the placebo group (adjusted odds ratio, 8.2 [95% CI, 1.0 to 65.3])

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In microglia, this shifts polarization from pro-inflammatory to anti-inflammatory states, reducing phagocytic hyperactivity and cytokine release

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Wegovy, approved in 2021, has shown significant results in promoting weight loss, with clinical trial participants losing an average of 17-18% of their body weight over 68 weeks

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