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What does evidence say about GLP-1 agonists and suicidal ideation

GLP-1RAs show modest SBP reductions (1.85.1 mmHg) and minimal DBP effects (~0.5 mmHg), though tirzepatide shows greater efficacy (~10.6 mmHg) in select populations

The high prevalence of comorbidities such as diabetes, visceral obesity, and aging, which contribute to systemic inflammation, plays a pivotal role in the pathogenesis and progression of HFpEF

Adverse psychiatric effects associated with GLP-1 RAs, including depression, anxiety, and suicidal ideation, are noted in pharmacovigilance analyses, with variations among different GLP-1 RAs
