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Adults with type 2 diabetes assigned an SGLT2 inhibitor or a GLP-1 receptor agonist during cardiovascular outcomes trials derived benefit from the therapies regardless of whether they were prescribed insulin, according to a meta-analysis.In an analysis of data across eight large, multiyear CV outcomes trials for three classes of diabetes agents, researchers also found that participants using

The combinations of DPP-4 inhibitors with metformin and/or sodium-glucose transport protein-2 inhibitors are rationalized in this paper, considering their complementary mechanisms of action
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GLP-1 release and vagal afferent activation mediate the beneficial metabolic and chronotherapeutic effects of D-allulose

Effects on birth weight percentiles were modest, with no increase in risk of large or small for gestational age and no difference in cesarean delivery rates.
