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Retatrutide simultaneously targets GLP-1, GIP, and glucagon receptors a mechanism that sets it apart from approved agents such as semaglutide and tirzepatide

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In the fall of 2025, several new indications are expected for GLP-1s such as: Injectable semaglutide (NN9931) for metabolic dysfunction-associated steatohepatitis (MASH) Injectable semaglutide (Wegovy) and tirzepatide (Zepbound) for heart failure with preserved ejection fraction (HFpEF) in patients with obesity Oral semaglutide (Rybelsus) for major adverse cardiovascular events (MACE) risk reduction in adults with type 2 diabetes (T2DM) and established CVD and/or CKD Moreover, we are closely monitoring the pipeline for oral GLP-1s

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Dahl D, Onishi Y, Norwood P et al (2022) Effect of subcutaneous tirzepatide vs placebo added to titrated insulin glargine on glycemic control in patients with type 2 diabetes: the SURPASS-5 randomized clinical trial