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494498 The role of GLP-1 in NASH has garnered attention due to its potential in regulating metabolism, improving insulin sensitivity, and exerting anti-inflammatory effects

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Algunos estudios demuestran una disminucin de 0.4-0.9% en HbA1c38,39 mientras que otros no demuestran beneficio en comparacin con la monoterapia con insulina40-42

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Brain uptake pharmacokinetics of incretin receptor agonists showing promise as Alzheimers and Parkinsons disease therapeutics

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Another example, reduction in amyloid beta plaques, can predict improvement of cognitive function for patients with Alzheimers disease

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Specifically, a study of zibotentan, a highly selective endothelin A ERA, in combination with dapagliflozin in participants with type 2 diabetes (NCT05570305) is currently underway, with similar phase 2 trials in type 1 diabetes being proposed

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The executive was referring to data from another late-stage trial where Orforglipron was found to be superior to Novo Nordisks oral Semaglutide in treating type-2 diabetes

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