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494498 The role of GLP-1 in NASH has garnered attention due to its potential in regulating metabolism, improving insulin sensitivity, and exerting anti-inflammatory effects

Algunos estudios demuestran una disminucin de 0.4-0.9% en HbA1c38,39 mientras que otros no demuestran beneficio en comparacin con la monoterapia con insulina40-42

Brain uptake pharmacokinetics of incretin receptor agonists showing promise as Alzheimers and Parkinsons disease therapeutics

Another example, reduction in amyloid beta plaques, can predict improvement of cognitive function for patients with Alzheimers disease

Specifically, a study of zibotentan, a highly selective endothelin A ERA, in combination with dapagliflozin in participants with type 2 diabetes (NCT05570305) is currently underway, with similar phase 2 trials in type 1 diabetes being proposed

The executive was referring to data from another late-stage trial where Orforglipron was found to be superior to Novo Nordisks oral Semaglutide in treating type-2 diabetes
