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One real-world evidence study found that patients receiving GLP-1 receptor agonists had a higher risk of ulcerative colitis compared to those on DPP-4 inhibitors (a different diabetes drug class)

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This is the trial most likely to anchor the FDA submission package

Excess weightespecially abdominal fatperpetuates a state of heightened immune activation that increases insulin resistance, fatty liver disease risk, and cardiovascular dysfunction