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Furthermore, these agents modulate inflammation, reduce apoptosis, and improve stem cell functions even under diabetic or inflammatory conditions

60 units per week from a 5 mg/mL semaglutide solution using a standard 100-unit insulin syringe equals 3 mg per week

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Here authors report the cryo-EM structure of GLP-1R bound to an ago-allosteric modulator in complex with heterotrimeric Gs which offers insights into the molecular details of ago-allosterism.

Patients had T2D and ASCVD and received semaglutide or a DPP-4i