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This is beneficial for wound healing but raises theoretical concerns about cancer

The conjugation and hydrolysis enzymes are located in both the cytosol and the endoplasmic reticulum of hepatocytes (and other tissues)

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The importance of this antioxidant pathway is illustrated in Nrf2 knockout mice in which lung neutrophil inflammation and pulmonary emphysema were evident as early as 8 weeks after cigarette smoke exposure, whereas wild-type mice showed no lung changes at 16 weeks