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While further confirmation of similar pathological mechanisms in humans is needed, modulation of Na V channel function remains an attractive strategy for treatment of sensory symptoms associated with CIPN

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However, there were also differences in other markers or genes, suggesting differentiation or transformation in the metastatic tumors compared to the primary site

Acknowledgements This work was supported in part by grants from Fondo de Investigacin Sanitaria (www.isciii.es) (PI15/ 00713) and GEHEP-SEIMC (GEHEP-004)