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Despite significant progress in clinical RNAi drug development, there remains considerable room for improvement in pharmacokinetics, pharmacodynamics, and strategies to mitigate toxicity (Setten et al., 2019)

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FIGURE 1 Growth hormone is mainly produced by the anterior pituitary gland, secreted in a pulsatile manner and under direct control of hypothalamic neuronal projections (Pombo et al., 2001), whose secretion is mainly regulated positively by growth hormone releasing hormone (GHRH), ghrelin (Dimaraki and Jaffe, 2006

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